Intra-arterial chemotherapy for the management of retinoblastoma
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Sep 29, 2021
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Abstract
Retinoblastoma is the most prevalent ocular tumor in childhood, with various clinical presentations. The main goals of treatment focus on survival and preservation of vision; however, treatment must be individualized. There are different therapeutic alternatives such as enucleation, systemic chemotherapy, radiotherapy and local therapies. Among the most recent alternatives is intra-arterial chemotherapy, which allows the direct administration of chemotherapeutic agents to intraocular malignant pathologies such as retinoblastoma through the ophthalmic artery. The objective of this article is to carry out a non-systematic review of the indications, advantages, disadvantages, technique, survival rates, costs, and complications of intra-arterial chemotherapy as a treatment for retinoblastoma.
Keywords
Retinoblastoma, Chemotherapy, Neoplasms, Eye enucleation, MelphalanRetinoblastoma, Quimioterapia, Neoplasias, Enucleación del ojo, Melfalán
References
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2. Ulos ART, Gómez-martínez R, Leal CA, Rivera-luna R. Los aspectos epidemiológicos en el retinoblastoma bilateral. Gac Medica Mex. 1995;131(5–6):527–31.
3. De Alba Campomanes BG. Enfermedades de los ojos y de la visión. Tenth Edit. Avery. Enfermedades del recién nacido. Elsevier Espa8#241;a, S.L.U.; 2018. 1550-1554 p.
4. Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H-J, Sastre-Garau X, Doz F. Retinoblastoma. EMC - Pediatría. 2014 Mar;49(1):1–9.
5. Tarek N, Herzog CE. Retinoblastoma Neoplasias gonadales y de células germinales. 21th Editi. Nelson. Tratado de pediatría. Elsevier Espa8#241;a, S.L.U.; 2017. 1-50 p.
6. Diez J. Oftalmología pediátrica para todos los días. AEPap. 2015;491–502.
7. Handal E. Diagnóstico diferencial de patología ocular en el infante. Honduras Pediátrica. 1998;19(1):9–10.
8. (SEOM) G de T en CH de la SE de OM. Guía de manejo de retinoblastoma. :1–6.
9. Rodriguez-galindo C, Orbach DB, Vanderveen D. Retinoblastoma. Pediatr Clin N Am. 2015;62:201–23.
10. Shields CL, Shields JA. Basic understanding of current classification and management of retinoblastoma. Curr Opin Ophthalmol. 2006;17(3):228–34.
11. Ortiz M V, Dunkel IJ. Retinoblastoma. J Child Neurol. 2015;1–10.
12. Rodriguez-Galindo C, Chantada GL, Haik BG, Wilson MW. Treatment of retinoblastoma: current status and future perspectives. Curr Treat Options Neurol. 2007 Jul;9(4):294–307.
13. Chantada G, Schaiquevich P. Management of Retinoblastoma in Children : Current Status. Pediatr Drugs. 2015;
14. Rao R, Honavar SG. Retinoblastoma. Indian J Pediatr. 2017 Dec;84(12):937–44.
15. Shields CL, Bianciotto CG, Jabbour P, Ramasubramanian A, Lally SE, Griffin GC, et al. Intra-arterial chemotherapy for retinoblastoma: report No. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol (Chicago, Ill 1960). 2011 Nov;129(11):1399–406.
16. Muen WJ, Kingston JE, Robertson F, Brew S, Sagoo MS, Reddy MA, et al. Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma. Ophthalmology [Internet]. 2012 Mar;119(3):611–6. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L51779308
17. Ortiz M V, Dunkel IJ. Retinoblastoma. J Child Neurol. 2016 Feb;31(2):227–36.
18. Shields JA, Parsons H, Shields CL, Giblin ME. The role of cryotherapy in the management of retinoblastoma. Am J Ophthalmol. 1989 Sep;108(3):260–4.
19. Shields CL, Santos MC, Diniz W, Gündüz K, Mercado G, Cater JR, et al. Thermotherapy for retinoblastoma. Arch Ophthalmol (Chicago, Ill 1960). 1999 Jul;117(7):885–93.
20. Shields JA, Shields CL, De Potter P. Photocoagulation of retinoblastoma. Int Ophthalmol Clin. 1993;33(3):95–9.
21. Hicsonmez A, Guney Y, Dirican B, Arslan Y, Atakul T, Uysal H. Challenges and differences in external radiation therapy for retinoblastoma: from standard techniques to new developments. Tumori. 2017;103(5):438–42.
22. Kaliki S, Palkonda VAR. Management of retinoblastoma with extraocular tumour extension. Community eye Heal. 2018;31(101):18–9.
23. Zanaty M, Barros G, Chalouhi N, Starke RM, Manasseh P, Tjoumakaris SI, et al. Update on Intra-Arterial Chemotherapy for Retinoblastoma. Sci World J. 2014;1–6.
24. Shields CL, Manjandavida FP, Lally SE, Pieretti G, Arepalli SA, Caywood EH, et al. Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma. Ophthalmology. 2014 Jul;121(7):1453–60.
25. Al Saiegh F, Chalouhi N, Sweid A, Mazza J, Mouchtouris N, Khanna O, et al. Intra-arterial chemotherapy for retinoblastoma via the transradial route: Technique, feasibility, and case series. Clin Neurol Neurosurg. 2020 Jul;194:105824.
26. Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, et al. Targeted retinoblastoma management : when to use intravenous , intra-arterial , periocular , and intravitreal chemotherapy. Curr Opin. 2014;25(5):374–85.
27. Shields CL, Jorge R, Say EAT, Magrath G, Alset A, Caywood E, et al. Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. Asia-Pacific J Ophthalmol (Philadelphia, Pa). 2016;5(2):97–103.
28. Shields CL, Shields JA. Review Intra-arterial chemotherapy for retinoblastoma : the beginning of a long journey. Clin Exp Ophthalmol. 2010;2009(November 2009):638–43.
29. CL Shields, EM Fulco, JD Arias, C Alarcon, M Pellegrini, P Rishi, S Kaliki CB and JS. Retinoblastoma frontiers with arterial, periocular, and intravitreal chemotherapy. Eye. 2013;27:253–64.
30. Reese AB, Hyman GA, Jr GRM. Treatment of retinoblastoma by radiation and Triethylenemelamine. Arch Ophthalmol. 1954;53(4):505–13.
31. Yamane T, Kaneko A, Mohri M. The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma. Int J Clin Oncol. 2004 Apr;9(2):69–73.
32. Abramson DH, Dunkel IJ, Brodie SE, Kim JW, Gobin YP. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results. Ophthalmology. 2008 Aug;115(8):1398–404, 1404.e1.
33. Jabbour, P; Chalouhi, N; Tjoumakaris, S; Gonzalez, F; Dumont, AS; Chitale, R; Rosenwasser, R; Bianiotto, CG; Shields C. Pearls and pitfalls of intraarterial chemotherapy for retinoblastoma. J Neurosurg Pediatr. 2012;10(September):175–81.
34. Klufas MA, Gobin YP, Marr B, Brodie SE, Dunkel IJ, Abramson DH. Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. Am J Neuroradiol. 2012 Sep;33(8):1608–14.
35. Suzuki S, Yamane T, Mohri M, Kaneko A. Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011 Oct;118(10):2081–7.
36. Jolly SS, Yusuf S, Cairns J, Niemelä K, Xavier D, Widimsky P, et al. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011 Apr;377(9775):1409–20.
37. Gobin YP, Dunkel IJ, Marr BP, Brodie SE, Abramson DH. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol (Chicago, Ill 1960). 2011 Jun;129(6):732–7.
38. Abramson DH, Dunkel IJ, Brodie SE, Marr B, Gobin YP. Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery). Ophthalmology. 2010 Aug;117(8):1623–9.
39. Schaiquevich P, Ceciliano A, Millan N, Taich P, Villasante F, Fandino AC, et al. Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma. Pediatr Blood Cancer. 2013 May;60(5):766–70.
40. Ross G, Lipper EG, Abramson D, Preiser L. The Development of Young Children With Retinoblastoma. Arch Pediatr Adolesc. 2001;155:80–3.
41. Peterson, EC; Elhammady, MS; Quintero-Wolff, S; Murray, TG; Aziz-Sultan M. Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors. J Neurosurg. 2011;114(June):1603–8.
42. Abramson DH, Marr BP, Dunkel IJ, Brodie S, Zabor EC, Driscoll SJ, et al. Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results. Br J Ophthalmol. 2012 Apr;96(4):499–502.
43. Thampi S, Hetts SW, Cooke DL, Stewart PJ, Robbins E, Banerjee A, et al. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Vol. 7, Clinical ophthalmology (Auckland, N.Z.). 2013. p. 981–9.
44. Abramson DH, Ellsworth RM, Grumbach N, Sturgis-Buckhout L, Haik BG. Retinoblastoma: correlation between age at diagnosis and survival. J Pediatr Ophthalmol Strabismus. 1986;23(4):174–7.
45. Abramson DH, Shields CL, Munier FL, Chantada GL. Treatment of Retinoblastoma in 2015: Agreement and Disagreement. JAMA Ophthalmol. 2015 Nov;133(11):1341–7.
46. Lim, LA; Dalvin, LA; Ancona-Lezama, D; Yu, MD; Jabbour, P, Shields C. Retinoblastoma vascular perfusion and intra-arterial chemotherapy cycle requirements. Clin Experiment Ophthalmol. 2019;1–9.
47. Ravindran K, Dalvin LA, Pulido JS, Brinjikji W. Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis. J Neurointerv Surg. 2019;11:1266–72.
48. Tse BC, Steinle JJ, Johnson D, Haik BG, Wilson MW. Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings. JAMA Ophthalmol. 2013 Jul;131(7):903–11.
49. Ancona-Lezama D, Dalvin LA, Lucio-Alvarez JA, Jabbour P, Shields CL. OPHTHALMIC VASCULAR EVENTS AFTER INTRA-ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments. Retina. 2019 Dec;39(12):2264–72.
50. Eagle, RC; Shields, C; Bianciotto, C; Jabbour, P; Shields J. Histopathologic Observations After Intra-arterial Chemotherapy for Retinoblastoma. Arch Ophthalmol. 2011;129(11):1416–21.
51. Aziz HA, Lasenna CE, Vigoda M, Fernandes C, Feuer W, Aziz-Sultan MA, et al. Retinoblastoma treatment burden and economic cost: impact of age at diagnosis and selection of primary therapy. Vol. 6, Clinical ophthalmology (Auckland, N.Z.). 2012. p. 1601–6.
2. Ulos ART, Gómez-martínez R, Leal CA, Rivera-luna R. Los aspectos epidemiológicos en el retinoblastoma bilateral. Gac Medica Mex. 1995;131(5–6):527–31.
3. De Alba Campomanes BG. Enfermedades de los ojos y de la visión. Tenth Edit. Avery. Enfermedades del recién nacido. Elsevier Espa8#241;a, S.L.U.; 2018. 1550-1554 p.
4. Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H-J, Sastre-Garau X, Doz F. Retinoblastoma. EMC - Pediatría. 2014 Mar;49(1):1–9.
5. Tarek N, Herzog CE. Retinoblastoma Neoplasias gonadales y de células germinales. 21th Editi. Nelson. Tratado de pediatría. Elsevier Espa8#241;a, S.L.U.; 2017. 1-50 p.
6. Diez J. Oftalmología pediátrica para todos los días. AEPap. 2015;491–502.
7. Handal E. Diagnóstico diferencial de patología ocular en el infante. Honduras Pediátrica. 1998;19(1):9–10.
8. (SEOM) G de T en CH de la SE de OM. Guía de manejo de retinoblastoma. :1–6.
9. Rodriguez-galindo C, Orbach DB, Vanderveen D. Retinoblastoma. Pediatr Clin N Am. 2015;62:201–23.
10. Shields CL, Shields JA. Basic understanding of current classification and management of retinoblastoma. Curr Opin Ophthalmol. 2006;17(3):228–34.
11. Ortiz M V, Dunkel IJ. Retinoblastoma. J Child Neurol. 2015;1–10.
12. Rodriguez-Galindo C, Chantada GL, Haik BG, Wilson MW. Treatment of retinoblastoma: current status and future perspectives. Curr Treat Options Neurol. 2007 Jul;9(4):294–307.
13. Chantada G, Schaiquevich P. Management of Retinoblastoma in Children : Current Status. Pediatr Drugs. 2015;
14. Rao R, Honavar SG. Retinoblastoma. Indian J Pediatr. 2017 Dec;84(12):937–44.
15. Shields CL, Bianciotto CG, Jabbour P, Ramasubramanian A, Lally SE, Griffin GC, et al. Intra-arterial chemotherapy for retinoblastoma: report No. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol (Chicago, Ill 1960). 2011 Nov;129(11):1399–406.
16. Muen WJ, Kingston JE, Robertson F, Brew S, Sagoo MS, Reddy MA, et al. Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma. Ophthalmology [Internet]. 2012 Mar;119(3):611–6. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L51779308
17. Ortiz M V, Dunkel IJ. Retinoblastoma. J Child Neurol. 2016 Feb;31(2):227–36.
18. Shields JA, Parsons H, Shields CL, Giblin ME. The role of cryotherapy in the management of retinoblastoma. Am J Ophthalmol. 1989 Sep;108(3):260–4.
19. Shields CL, Santos MC, Diniz W, Gündüz K, Mercado G, Cater JR, et al. Thermotherapy for retinoblastoma. Arch Ophthalmol (Chicago, Ill 1960). 1999 Jul;117(7):885–93.
20. Shields JA, Shields CL, De Potter P. Photocoagulation of retinoblastoma. Int Ophthalmol Clin. 1993;33(3):95–9.
21. Hicsonmez A, Guney Y, Dirican B, Arslan Y, Atakul T, Uysal H. Challenges and differences in external radiation therapy for retinoblastoma: from standard techniques to new developments. Tumori. 2017;103(5):438–42.
22. Kaliki S, Palkonda VAR. Management of retinoblastoma with extraocular tumour extension. Community eye Heal. 2018;31(101):18–9.
23. Zanaty M, Barros G, Chalouhi N, Starke RM, Manasseh P, Tjoumakaris SI, et al. Update on Intra-Arterial Chemotherapy for Retinoblastoma. Sci World J. 2014;1–6.
24. Shields CL, Manjandavida FP, Lally SE, Pieretti G, Arepalli SA, Caywood EH, et al. Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma. Ophthalmology. 2014 Jul;121(7):1453–60.
25. Al Saiegh F, Chalouhi N, Sweid A, Mazza J, Mouchtouris N, Khanna O, et al. Intra-arterial chemotherapy for retinoblastoma via the transradial route: Technique, feasibility, and case series. Clin Neurol Neurosurg. 2020 Jul;194:105824.
26. Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, et al. Targeted retinoblastoma management : when to use intravenous , intra-arterial , periocular , and intravitreal chemotherapy. Curr Opin. 2014;25(5):374–85.
27. Shields CL, Jorge R, Say EAT, Magrath G, Alset A, Caywood E, et al. Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. Asia-Pacific J Ophthalmol (Philadelphia, Pa). 2016;5(2):97–103.
28. Shields CL, Shields JA. Review Intra-arterial chemotherapy for retinoblastoma : the beginning of a long journey. Clin Exp Ophthalmol. 2010;2009(November 2009):638–43.
29. CL Shields, EM Fulco, JD Arias, C Alarcon, M Pellegrini, P Rishi, S Kaliki CB and JS. Retinoblastoma frontiers with arterial, periocular, and intravitreal chemotherapy. Eye. 2013;27:253–64.
30. Reese AB, Hyman GA, Jr GRM. Treatment of retinoblastoma by radiation and Triethylenemelamine. Arch Ophthalmol. 1954;53(4):505–13.
31. Yamane T, Kaneko A, Mohri M. The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma. Int J Clin Oncol. 2004 Apr;9(2):69–73.
32. Abramson DH, Dunkel IJ, Brodie SE, Kim JW, Gobin YP. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results. Ophthalmology. 2008 Aug;115(8):1398–404, 1404.e1.
33. Jabbour, P; Chalouhi, N; Tjoumakaris, S; Gonzalez, F; Dumont, AS; Chitale, R; Rosenwasser, R; Bianiotto, CG; Shields C. Pearls and pitfalls of intraarterial chemotherapy for retinoblastoma. J Neurosurg Pediatr. 2012;10(September):175–81.
34. Klufas MA, Gobin YP, Marr B, Brodie SE, Dunkel IJ, Abramson DH. Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. Am J Neuroradiol. 2012 Sep;33(8):1608–14.
35. Suzuki S, Yamane T, Mohri M, Kaneko A. Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011 Oct;118(10):2081–7.
36. Jolly SS, Yusuf S, Cairns J, Niemelä K, Xavier D, Widimsky P, et al. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011 Apr;377(9775):1409–20.
37. Gobin YP, Dunkel IJ, Marr BP, Brodie SE, Abramson DH. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol (Chicago, Ill 1960). 2011 Jun;129(6):732–7.
38. Abramson DH, Dunkel IJ, Brodie SE, Marr B, Gobin YP. Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery). Ophthalmology. 2010 Aug;117(8):1623–9.
39. Schaiquevich P, Ceciliano A, Millan N, Taich P, Villasante F, Fandino AC, et al. Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma. Pediatr Blood Cancer. 2013 May;60(5):766–70.
40. Ross G, Lipper EG, Abramson D, Preiser L. The Development of Young Children With Retinoblastoma. Arch Pediatr Adolesc. 2001;155:80–3.
41. Peterson, EC; Elhammady, MS; Quintero-Wolff, S; Murray, TG; Aziz-Sultan M. Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors. J Neurosurg. 2011;114(June):1603–8.
42. Abramson DH, Marr BP, Dunkel IJ, Brodie S, Zabor EC, Driscoll SJ, et al. Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results. Br J Ophthalmol. 2012 Apr;96(4):499–502.
43. Thampi S, Hetts SW, Cooke DL, Stewart PJ, Robbins E, Banerjee A, et al. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Vol. 7, Clinical ophthalmology (Auckland, N.Z.). 2013. p. 981–9.
44. Abramson DH, Ellsworth RM, Grumbach N, Sturgis-Buckhout L, Haik BG. Retinoblastoma: correlation between age at diagnosis and survival. J Pediatr Ophthalmol Strabismus. 1986;23(4):174–7.
45. Abramson DH, Shields CL, Munier FL, Chantada GL. Treatment of Retinoblastoma in 2015: Agreement and Disagreement. JAMA Ophthalmol. 2015 Nov;133(11):1341–7.
46. Lim, LA; Dalvin, LA; Ancona-Lezama, D; Yu, MD; Jabbour, P, Shields C. Retinoblastoma vascular perfusion and intra-arterial chemotherapy cycle requirements. Clin Experiment Ophthalmol. 2019;1–9.
47. Ravindran K, Dalvin LA, Pulido JS, Brinjikji W. Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis. J Neurointerv Surg. 2019;11:1266–72.
48. Tse BC, Steinle JJ, Johnson D, Haik BG, Wilson MW. Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings. JAMA Ophthalmol. 2013 Jul;131(7):903–11.
49. Ancona-Lezama D, Dalvin LA, Lucio-Alvarez JA, Jabbour P, Shields CL. OPHTHALMIC VASCULAR EVENTS AFTER INTRA-ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments. Retina. 2019 Dec;39(12):2264–72.
50. Eagle, RC; Shields, C; Bianciotto, C; Jabbour, P; Shields J. Histopathologic Observations After Intra-arterial Chemotherapy for Retinoblastoma. Arch Ophthalmol. 2011;129(11):1416–21.
51. Aziz HA, Lasenna CE, Vigoda M, Fernandes C, Feuer W, Aziz-Sultan MA, et al. Retinoblastoma treatment burden and economic cost: impact of age at diagnosis and selection of primary therapy. Vol. 6, Clinical ophthalmology (Auckland, N.Z.). 2012. p. 1601–6.
How to Cite
Gómez Vega, J. C., Ocampo-Navia, M. I., Botero-Trujillo, J. J. ., Fandiño-Hidalgo, R. E., & Puentes Vargas, J. C. (2021). Intra-arterial chemotherapy for the management of retinoblastoma. Universitas Medica, 62(4). https://doi.org/10.11144/Javeriana.umed62-4.quim
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