Published Feb 6, 2017



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Ricardo Antonio Sánchez Forero

Lorena Bedoya

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Abstract

Metastasic lesions in posterior fosa in with
leptomeningeal association in patients with
breast cancer are unusual, with a mean survival
after treatment of 4 to 6 months. Literature
describe different treatment options. This
location could be difficult and can involve vital
structures in Central Nervous System (CNS),
requiring opportune treatment, and then avoiding
complications related with the prognosis and
survival. The case is reported on a 57 yearsold woman with an unique metastasic lesion in
the superior aspect of cerebellar vermis with
leptomeningeal infiltration associated, treated
with unique dose radiosurgery. We follow up the
patient for 10 months and we notice clinical and
neurological improvement

Keywords

radiosurgery, meningeal neoplasms, brain neoplasm, breast neoplasms, neoplasm metastasis.radiocirugía, neoplasias meníngeas, neoplasias encefálicas, neoplasias de la mama, metástasis de la neoplasia.

References
1. Patchell RA. The management of
brain metastases. Cancer Treat Rev.
2003;29(6):533-40.

2. Suh JH. Stereotactic radiosurgery for
the management of brain metastases. N
Engl J Med. 2010;362(12):1119-27. doi:
10.1056/NEJMct0806951

3. de la Monte SM, Hutchins GM, Moore
GW. Estrogen and progesterone receptor in
prediction of metastasic behavior of breast
carcinoma. Am J Med 1984;76:11-7.

4. Scott B, Kesari S. Leptomenigeal metastases
in breast cancer. Am J Cancer Res.
2013;3(2):117-26.

5. Frisk G, Svensson T. Incidence and time
trends of brain metastases admissions
among breast cancer patients in Sweden.
Br J Cancer 2012 may 22;106:1850-3.
doi: 10.1038/bjc.2012.163.

6. Kesari S, Batchelor TT. Leptomeningeal
metastases. Neurol Clin. 2003 Feb;21:
25-66.

7. Altundag K, Bondy ML, Mirza N, Rivera
E. Clinico-pathologic characteristics
and prognostic factors in 420 metastasic
breast cancer patients with central
nervous system metastases. Cancer.
2007;110:2640-7.

8. Boogered W, van den bent MJ. The relevante
of intraventricular chemotherapy
for Leptomeningeal metastases in breast
cáncer. Eur J Cancer. 2004;40:2726-33.

9. Hitchins RN, Woods RL. A prospective
randomized trial of single-agent versus
combinación chemotherapy in meningeal
carcinomatosis. J Clin Oncol.
1987;5:1655-62.

10. Slimane K, André F, Delaloge S, Dunant
A, Perez A, Grenier J, et al. Risk factors
for brain relapse in patients with metastatic
breast cancer. Ann Oncol. 2004
Nov;15(11):1640-4. doi: 10.1093/annonc
/mdh432

11. Gauthier H, Guilhaume MN, Pierga JY.
Survival of breast cancer patients with
meningeal carcinomatosis. Ann Oncol.
2010 Nov;21:2183-7.

12. Rudnicka H, Niwinska N, Murawka M.
Breast cancer leptomeningeal metastases-
the role of multimodality treatment. J
Neurooncol. 2007;84(1):57-62.

13. Clarot F, Philippin-Lauridant G, Ouvrier
MJ, Nakry T, Laberge-Le-Couteulx S,
Guillemet C, et al. Clinical improvement
and survival in breast cancer leptomeningeal
metastases correlate with the cytologic
response to intratecal chemotherapy.
J Neurooncol. 2009;95(3):421-6. doi:
10.1007/s11060-009-9940-2

14. Hermann B, Hültenschmidt B, Sautter-
Bihl ML. Radiotherapy of the neuroaxis
for paliative treatment of leptomeningeal.
Strahlenther Onkol. 2001;177(4):195-9.
How to Cite
Sánchez Forero, R. A., & Bedoya, L. (2017). Radiosurgery for Metastatic Posterior Fossa Lesion with Leptomeningeal Infiltration: Case Presentation and Literature Review. Universitas Medica, 57(3), 383–390. https://doi.org/10.11144/Javeriana.umed57-3.rlmf
Section
Case Reports

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