The modern University is born of the reform of Humboldt, who introduced sciences in full expansion and contributed decisively to its development. But Humboldt was also aware that the University should provide a general culture, rather than a specialized professional formation, to face the fundamental and global problems that are presented to us in this century in an increasingly vital and urgent way. This principle becomes even more valid now that we are experiencing a cultural crisis: the culture of our century needs communication and exchange between scientific knowledge and humanistic culture. However, instead of irrigating as a general competence should, the disciplines are enclosed in themselves; the fragmentation of knowledge disintegrates fundamental and global problems. It is then to those problems that a new reform of the University should be dedicated, which would be no less historical than Humboldt's.